Dysregulated Tfr/Tfh2 cells in patients with polycystic ovarian syndrome

Recent research revealed the pathogenic role of B cells in the pathogenesis of polycystic ovary syndrome (PCOS), while the Tfh cell plays a critical role in the B cell mediated autoantibody production and humoral immunity, but had not been investigated in PCOS patients. The frequency of Tfh and B ce...

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Bibliographic Details
Published in:Journal of reproductive immunology 2023-09, Vol.159, p.104137, Article 104137
Main Authors: Xuan, Xiaofang, Ye, Chunmei, Zhao, Jiwei, Shen, Fuping, Chen, Yanxia, Liu, Jinlin
Format: Article
Language:English
Subjects:
Follicular regulatory T (Tfr) cell
Pathogenesis
Plasma cell
Polycystic ovary syndrome
T follicular helper (Tfh) cell
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Summary:Recent research revealed the pathogenic role of B cells in the pathogenesis of polycystic ovary syndrome (PCOS), while the Tfh cell plays a critical role in the B cell mediated autoantibody production and humoral immunity, but had not been investigated in PCOS patients. The frequency of Tfh and B cell subsets (Tfh1, Tfh2, Tfh17, naïve B, memory B, and plasma cells) in the peripheral blood of 21 PCOS patients and 15 healthy controls were investigated by flow cytometry. And the levels of follicle-stimulating hormone, luteinizing hormone, testosterone, prolactin and estradiol progesterone were measured by using the immunoluminescence method. Also, the associations between these hormone levels and Tfh cell subsets or B cell subsets were analyzed. No significant difference was observed in total Tfh cells between 21 PCOS patients and 15 healthy controls (p > 0.05). But the percentages of Tfh2 and plasma cells were significantly higher in 21 PCOS patients compared to 15 healthy controls (p 
ISSN:0165-0378
1872-7603
1872-7603
DOI:10.1016/j.jri.2023.104137