Improved effectiveness of an increased dose of griseofulvin for treating Tinea capitis among refugee children in Israel: A retrospective cohort study

• Published in: Mycoses 2023-12, Vol.66 (12), p.1064-1070
• Main Authors: Kassem, R, Barzilai, A, Baum, S, Kempfner, A, Pavlotsky, F
• Format: Article
• Language: English
• Subjects: Children; Cohort analysis; Drug dosages; Fungal infections; Griseofulvin; Refugees; Terbinafine; Tinea capitis
• ISSN: 0933-7407; 1439-0507
• DOI: 10.1111/myc.13651

BackgroundTinea capitis (TC), a fungal infection that occurs in children, is primarily caused by dermatophytes such as Trichophyton and Microsporum species. For Trichophyton species, treatment with terbinafine is considered more effective than griseofulvin treatment. Specific populations, such as refugee children, are more susceptible to TC.ObjectiveThis study aimed to describe and compare the response to treatment among Israeli and refugee children with TC.Patients/MethodsWe retrospectively reviewed data collected on refugee and Israeli children with TC between January 2004 and January 2020.ResultsOverall, 3358 children with TC (refugees: 1497; Israelis: 1861) were identified. Among these, 86% of the refugee children had TC caused by Trichophyton violaceum, 65% of the Israeli children had TC caused by Microsporum canis and 83% of all children were treated with griseofulvin. Overall, 14% of the refugees showed a partial response to a griseofulvin dose of ≤25 mg/kg/day; however, they showed a complete response upon increasing the dose to ≥30 mg/kg/day. No significant adverse effects were observed.ConclusionThe over‐crowded day care centres and dense living make refugee children more susceptible to TC than the general population, and griseofulvin dosage adjustment is necessary. TC, due to Trichophyton species, could benefit from receiving an increased dose of griseofulvin in a suspension form, which is cheaper than terbinafine.