Relationships Between Inflammatory Parameters Derived From Complete Blood Count and Quantitative Flow Ratio in Patients With Stable Coronary Artery Disease

To investigate the relationships between inflammatory parameters, including neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII), and quantitative flow ratio (QFR) in stable coronary artery disease (...

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Published in:Angiology 2025-01, Vol.76 (1), p.51-57
Main Authors: Xie, Yanqing, Cen, Han, Wang, Li, Cheng, Keai, Huang, Li, Lu, Haoxuan, Ji, Lili, Chen, Yudan, Zhou, Zhong, Yang, Zhuo, Jing, Sheng, Zhu, Haibo, Chen, Kan, Chen, Si, He, Wenming
Format: Article
Language:English
Subjects:
Aged
Blood Cell Count
Blood Platelets
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - physiopathology
Cross-Sectional Studies
Female
Humans
Inflammation - blood
Logistic Models
Lymphocyte Count
Lymphocytes
Male
Middle Aged
Monocytes
Multivariate Analysis
Neutrophils
Odds Ratio
Platelet Count
Predictive Value of Tests
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Summary:To investigate the relationships between inflammatory parameters, including neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII), and quantitative flow ratio (QFR) in stable coronary artery disease (CAD) patients (n = 450) enrolled in this cross-sectional study. Logistic regression was performed to evaluate the associations of NLR, PLR, MLR, and SII evaluated as continuous and binary variables with QFR ≤0.80. When treated as continuous variables, lnNLR was associated with QFR ≤0.80 with borderline significance in univariable (odds ratio (OR) = 1.60, p = .05) and multivariable analysis (OR = 1.72, p = .05), while lnMLR was associated with QFR ≤0.80 significantly in univariable analysis (OR = 1.87, p = .03) and with borderline significance in multivariable analysis (OR = 1.91, p = .05). When treated as binary variables, high levels of MLR and SII were significantly associated with QFR ≤0.80 in univariable (MLR: OR = 1.91, p = .02; SII: OR = 2.42, p = .006) and multivariable analysis (MLR: OR = 1.83, p = .04; SII: OR = 2.19, p = .02). NLR, MLR, and SII, but not PLR, were significantly associated with the severity of coronary physiology in stable CAD patients.
ISSN:0003-3197
1940-1574
1940-1574
DOI:10.1177/00033197231197804