Anti-PD1 rechallenge in combination with anti-angiogenesis or anti-EGFR treatment beyond progression in recurrent/metastatic nasopharyngeal carcinoma patients

We aim to evaluate the efficacy and safety of anti-PD1 rechallenge in combination with anti-angiogenesis or anti-EGFR treatment in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC) patients who progressed to previous anti-PD1 therapy. Enrolled patients were divided into a combination group and...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2023-10, Vol.190, p.104113, Article 104113
Main Authors: Jiang, Yaofei, Fang, Ting, Lu, Nian, Bei, Weixin, Dong, Shuhui, Xia, Weixiong, Liang, Hu, Xiang, Yanqun
Format: Article
Language:English
Subjects:
Anti-angiogenesis
EGFR inhibitors
Nasopharyngeal carcinoma
PD1 inhibitors
Prognosis
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Summary:We aim to evaluate the efficacy and safety of anti-PD1 rechallenge in combination with anti-angiogenesis or anti-EGFR treatment in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC) patients who progressed to previous anti-PD1 therapy. Enrolled patients were divided into a combination group and a chemotherapy only group. A total of 145 patients were enrolled. The median progress-free survival (mPFS) was 7.9 months and 4.4 months, respectively for the two groups. The combination group exhibited significantly longer PFS (HR=0.363, p 
ISSN:1040-8428
1879-0461
1879-0461
DOI:10.1016/j.critrevonc.2023.104113