Recent advances in Zn2+ imaging: from organelles to in vivo applications

Zn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this t...

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Bibliographic Details
Published in:Current opinion in chemical biology 2023-10, Vol.76, p.102378-102378, Article 102378
Main Authors: Fang, Hongbao, Li, Yaheng, Yang, Xiuzhi, Chen, Yuncong, Guo, Zijian, He, Weijiang
Format: Article
Language:English
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Summary:Zn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in organelles, cells, and live organisms reported over the past two years. We aim to provide inspiration for the design of novel Zn2+ probes for multi-level monitoring and deepen the understanding of Zn2+ biology.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2023.102378