Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children

• Published in: Autism research 2023-11, Vol.16 (11), p.2077-2089
• Main Authors: Finn, Caroline E, Han, Gloria T, Naples, Adam J, Wolf, Julie M, McPartland, James C
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Age factors; Autism; Autism Spectrum Disorder; Autistic children; Autistic Disorder; Bivariate analysis; Child; Children; Cognition; Cognitive ability; Diagnostic systems; EEG; Electroencephalography; Electroencephalography - methods; Humans; Intelligence; Maturation
• ISSN: 1939-3792; 1939-3806
• DOI: 10.1002/aur.3017

Electroencephalographic peak alpha frequency (PAF) is a marker of neural maturation that increases with age throughout childhood. Distinct maturation of PAF is observed in children with autism spectrum disorder such that PAF does not increase with age and is instead positively associated with cognitive ability. The current study clarifies and extends previous findings by characterizing the effects of age and cognitive ability on PAF between diagnostic groups in a sample of children and adolescents with and without autism spectrum disorder. Resting EEG data and behavioral measures were collected from 45 autistic children and 34 neurotypical controls aged 8 to 18 years. Utilizing generalized additive models to account for nonlinear relations, we examined differences in the joint effect of age and nonverbal IQ by diagnosis as well as bivariate relations between age, nonverbal IQ, and PAF across diagnostic groups. Age was positively associated with PAF among neurotypical children but not among autistic children. In contrast, nonverbal IQ but not age was positively associated with PAF among autistic children. Models accounting for nonlinear relations revealed different developmental trajectories as a function of age and cognitive ability based on diagnostic status. Results align with prior evidence indicating that typical age-related increases in PAF are absent in autistic children and that PAF instead increases with cognitive ability in these children. Findings suggest the potential of PAF to index distinct trajectories of neural maturation in autistic children.