Seroprevalence and incidence of hepatitis E virus infection in the general population of Iwate prefecture, Japan: A retrospective cohort study

Aim Hepatitis E virus (HEV) causes subclinical or acute self‐limiting hepatitis. We surveyed the current seroprevalence and incidence of HEV infection among the general population in Iwate Prefecture, Japan, where the endemic infection is presumed to be low. Methods Between 2014 and 2016, we recruit...

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Published in:Hepatology research 2024-01, Vol.54 (1), p.24-31
Main Authors: Yoshida, Yuichi, Ito, Asami, Eto, Hisashi, Suzuki, Akiko, Abe, Tamami, Endo, Kei, Kakisaka, Keisuke, Oikawa, Takayoshi, Kuroda, Hidekatsu, Miyasaka, Akio, Matsumoto, Takayuki, Takahashi, Masaharu, Okamoto, Hiroaki
Format: Article
Language:English
Subjects:
DNA-directed RNA polymerase
Hepatitis
hepatitis E virus
Immunoglobulin G
incidence
Infections
Reverse transcription
Seroconversion
Serology
seroprevalence
seroreversion
Viruses
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Summary:Aim Hepatitis E virus (HEV) causes subclinical or acute self‐limiting hepatitis. We surveyed the current seroprevalence and incidence of HEV infection among the general population in Iwate Prefecture, Japan, where the endemic infection is presumed to be low. Methods Between 2014 and 2016, we recruited individuals from Iwate Prefecture, Japan, who visited a general medical work‐up program. Serum anti‐HEV antibody and HEV RNA were measured twice, with an interval of 2 years. Anti‐HEV antibody was measured with enzyme‐linked immunosorbent assay and HEV RNA with reverse transcription‐polymerase chain reaction. Results Study participants comprised 1284 Japanese (650 men and 634 women) with age ranging 20–89 years. A total of 90 participants were found to be positive for anti‐HEV immunoglobulin G on the first visit, with a prevalence of 7.0% (95% confidence interval [CI] 5.6%–8.4%). Seroprevalence was higher in men than in women (10.1% vs. 3.7%, p 
ISSN:1386-6346
1872-034X
DOI:10.1111/hepr.13961