Analysis of tissue lipidomics and computed tomography pulmonary fat attenuation volume ( CT PFAV ) in idiopathic pulmonary fibrosis

Aberrant cell lipid metabolism has been described in IPF but the underlying mechanisms are underexplored. In this study, chest CT is used to assess pulmonary fat attenuation volume (PFAV) in IPF. CT PFAV correlates with spirometry and IPF radiological markers. With further validation, CT PFAV could...

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Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2023-11, Vol.28 (11), p.1043-1052
Main Authors: O'Callaghan, Marissa, Duignan, John, Tarling, Elizabeth J., Waters, Darragh K., McStay, Megan, O'Carroll, Orla, Bridges, James P., Redente, Elizabeth F., Franciosi, Alessandro N., McGrath, Emmet E., Butler, Marcus W., Dodd, Jonathan D., Fabre, Aurelie, Murphy, David J., Keane, Michael P., McCarthy, Cormac
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Computed tomography
Fibrosis
Lipids
Lung diseases
Pulmonary fibrosis
Respiratory diseases
Respiratory function
Serum lipids
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Summary:Aberrant cell lipid metabolism has been described in IPF but the underlying mechanisms are underexplored. In this study, chest CT is used to assess pulmonary fat attenuation volume (PFAV) in IPF. CT PFAV correlates with spirometry and IPF radiological markers. With further validation, CT PFAV could be used as a disease severity biomarker.
ISSN:1323-7799
1440-1843
DOI:10.1111/resp.14582