Estimated plasma volume is not a robust indicator of the severity of congestion in patients with heart failure

Congestion is the main cause of morbidity and a prime determinant of survival in patients with heart failure (HF). However, the assessment of congestion is subjective and estimation of plasma volume (ePV) has been suggested as a more objective measure of congestion. This study aimed to explore the r...

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Bibliographic Details
Published in:The American journal of the medical sciences 2023-11, Vol.366 (5), p.374-382
Main Authors: Çetin Güvenç, Rengin, Güvenç, Tolga Sinan, Akıl, Mehmet Ata, Bekar, Lütfü, Vural, Mustafa Gökhan, Yılmaz, Mehmet Birhan
Format: Article
Language:English
Subjects:
Congestion
Heart failure
Mortality
Plasma volume
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Summary:Congestion is the main cause of morbidity and a prime determinant of survival in patients with heart failure (HF). However, the assessment of congestion is subjective and estimation of plasma volume (ePV) has been suggested as a more objective measure of congestion. This study aimed to explore the relationships and interactions between ePV, the severity of congestion and survival using a nationwide registry. Of the 1054 patients with HF enrolled in the registry, 769 had sufficient data to calculate ePV (using the Duarte, Kaplan, and Hakim equations) and relative plasma volume status (rPVS), and these patients were subsequently included in the present analysis. The severity of congestion was assessed using a 6-point congestion score (CS). Patients were divided into three groups according to the degree of congestion. Out of four equations tested, only ePVDuarte and rPVS were statistically higher in patients with severe congestion as compared to patients with no congestion (p
ISSN:0002-9629
1538-2990
DOI:10.1016/j.amjms.2023.08.008