Enzymatic Oxy‐ and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives

Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers the possibility to minimize downstream processing and waste production. In this review, we illustrate various recen...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2023-11, Vol.62 (48), p.e202309012-n/a
Main Authors: Grandi, Eleonora, Feyza Özgen, Fatma, Schmidt, Sandy, Poelarends, Gerrit J.
Format: Article
Language:English
Subjects:
Amination
Atom economy
Biocatalysis
Biocatalysts
Enzymatic Cascades
Enzymes
Enzymes, Immobilized
Flow system
Nanomaterials
Nanotechnology
Oxygenation
Polymers
Prepolymers
Substrates
Sustainable Chemistry
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Summary:Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers the possibility to minimize downstream processing and waste production. In this review, we illustrate various recent efforts in the development of multi‐step syntheses involving C−O and C−N bond‐forming enzymes to produce high value‐added compounds, such as pharmaceuticals and polymer precursors. Both in vitro and in vivo examples are discussed, revealing the respective advantages and drawbacks. The use of engineered enzymes to boost the cascades outcome is also addressed and current co‐substrate and cofactor recycling strategies are presented, highlighting the importance of atom economy. Finally, tools to overcome current challenges for multi‐enzymatic oxy‐ and amino‐functionalization reactions are discussed, including flow systems with immobilized biocatalysts and cascades in confined nanomaterials. Oxygenation and amination reactions are widespread in synthetic chemistry to produce valuable compounds. Nowadays, the importance of sustainable strategies to introduce oxygen and amino functionalities into organic molecules is increasing. This review discusses recent examples of multi‐step biocatalytic cascades involving oxy‐ and amino‐functionalization reactions to produce value‐added compounds such as pharmaceuticals and polymer precursors.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202309012