Suspected Buprenorphine-Precipitated Opioid Withdrawal following Intercourse: A Case Report

Buprenorphine, a partial mu-opioid receptor agonist, is a commonly prescribed medication for opioid use disorder (OUD). There is evidence that drugs may enter the male genitourinary tract by an ion-trapping process, based on the lipid solubility and degree of ionization (1). While little is known ab...

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Bibliographic Details
Published in:Journal of pain & palliative care pharmacotherapy 2023-10, Vol.37 (4), p.314-316
Main Authors: Lynch, Davene, Chitty, Lyndsey, Johnson, Brittany, Hoefnagel, Amie L.
Format: Article
Language:English
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Summary:Buprenorphine, a partial mu-opioid receptor agonist, is a commonly prescribed medication for opioid use disorder (OUD). There is evidence that drugs may enter the male genitourinary tract by an ion-trapping process, based on the lipid solubility and degree of ionization (1). While little is known about the pharmacokinetics of drugs in seminal fluid, pH is thought to play an integral role. Limited evidence exists surrounding cervical absorption of drugs via seminal fluid transmission. This also prompts survey of the frequency of this event and the influence on treatment within this population.
ISSN:1536-0288
1536-0539
DOI:10.1080/15360288.2023.2250344