Suspected Buprenorphine-Precipitated Opioid Withdrawal following Intercourse: A Case Report

Buprenorphine, a partial mu-opioid receptor agonist, is a commonly prescribed medication for opioid use disorder (OUD). There is evidence that drugs may enter the male genitourinary tract by an ion-trapping process, based on the lipid solubility and degree of ionization (1). While little is known ab...

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Published in:Journal of pain & palliative care pharmacotherapy 2023-10, Vol.37 (4), p.314-316
Main Authors: Lynch, Davene, Chitty, Lyndsey, Johnson, Brittany, Hoefnagel, Amie L.
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Language:English
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description Buprenorphine, a partial mu-opioid receptor agonist, is a commonly prescribed medication for opioid use disorder (OUD). There is evidence that drugs may enter the male genitourinary tract by an ion-trapping process, based on the lipid solubility and degree of ionization (1). While little is known about the pharmacokinetics of drugs in seminal fluid, pH is thought to play an integral role. Limited evidence exists surrounding cervical absorption of drugs via seminal fluid transmission. This also prompts survey of the frequency of this event and the influence on treatment within this population.
doi_str_mv 10.1080/15360288.2023.2250344
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title Suspected Buprenorphine-Precipitated Opioid Withdrawal following Intercourse: A Case Report
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