Picoscope, a new label-free biosensor

A new label-free biosensing spectral correlation method based on measurements of a correlation signal of two interferometers in an original optical scheme has been developed. One of the interferometers used as a biochip is a simple microscope cover glass without any additional metal or dielectric fi...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2005-11, Vol.111 (Complete), p.500-504
Main Authors: Nikitin, P.I., Gorshkov, B.G., Nikitin, E.P., Ksenevich, T.I.
Format: Article
Language:English
Subjects:
Biosensors
Interference
Nano- and pico-technologies
Optics
Picoscope
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Summary:A new label-free biosensing spectral correlation method based on measurements of a correlation signal of two interferometers in an original optical scheme has been developed. One of the interferometers used as a biochip is a simple microscope cover glass without any additional metal or dielectric film. A biosensor named “Picoscope” has been developed for real-time simultaneous detection of several biological agents by measuring picometer-range changes of the thickness of different biorecognition spots on the biochip surface. The application area of the Picoscope can be as wide as that of traditional optical microscope. However, the Picoscope can provide much more comprehensive information with outstanding resolution in depth, for example, for measuring molecular binding kinetics, monitoring of assembling and detaching in molecular structures, etc. The Picoscope technology will significantly increase the power of research instruments for bio-, nano- and pico-technologies.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2005.03.043