TP53 status and impact on AML prognosis within the ELN 2022 risk classification

This study reports the following: (1) frequency of TP53 comutation within each component of the European LeukemiaNet 2022 acute myeloid leukemia risk classification, (2) relevance of TP53 mutated variant allelic fraction

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Bibliographic Details
Published in:Blood 2023-12, Vol.142 (23), p.2029-2033
Main Authors: Fleming, Shaun, Tsai, Cheng-Hong, Morris, Rhiannon, Hou, Hsin-An, Wei, Andrew H.
Format: Article
Language:English
Subjects:
Abnormal Karyotype
Humans
Leukemia, Myeloid, Acute - genetics
Mutation
Myelodysplastic Syndromes - genetics
Prognosis
Tumor Suppressor Protein p53 - genetics
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Description
Summary:This study reports the following: (1) frequency of TP53 comutation within each component of the European LeukemiaNet 2022 acute myeloid leukemia risk classification, (2) relevance of TP53 mutated variant allelic fraction
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2023020855