Effect of vitamin D receptor gene BsmI polymorphism on hospitalization of SARS-CoV-2 positive patients

Low vitamin D levels and adverse effects have been reported in SARS-COV-2 positive patients. This study examined the effect of the vitamin D receptor gene BsmI polymorphism on SARS-COV-2 positive patients. A total of 80 SARS-COV-2 positive inpatients were included in the study, and 110 healthy indiv...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2024, Vol.43 (3), p.264-275
Main Authors: Aci, Recai, Keskin, Adem, Yigit, Serbulent, Sezer, Ozlem, Kaya, Muhammet Taha
Format: Article
Language:English
Subjects:
Alleles
BsmI polymorphism
C-reactive protein
Cholecalciferol
COVID-19
COVID-19 - genetics
Ferritin
Ferritins - genetics
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Hospitalization
Humans
Leukocytes
Lymphocytes
Polymorphism
Procalcitonin
Procalcitonin - genetics
Prothrombin
Receptors, Calcitriol - genetics
SARS-COV-2
SARS-CoV-2 - genetics
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Thromboplastin
Vitamin D
Vitamin D3
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Summary:Low vitamin D levels and adverse effects have been reported in SARS-COV-2 positive patients. This study examined the effect of the vitamin D receptor gene BsmI polymorphism on SARS-COV-2 positive patients. A total of 80 SARS-COV-2 positive inpatients were included in the study, and 110 healthy individuals were included as a control group. The 25-(OH) vitamin D3, lymphocyte, and activated partial thromboplastin time levels of SARS-COV-2 positive patients were lower than those of the control group. The prothrombin time (PT), international normalized ratio (INR), D-dimer, C-reactive protein (CRP), procalcitonin, and ferritin levels of SARS-COV-2 positive patients were higher than those of the control group. A negative correlation was found between 25-(OH) vitamin D3 levels and white blood cell count, PT, INR, D-dimer, CRP, procalcitonin, and ferritin levels in SARS-COV-2 positive patients. The 25-(OH) vitamin D3 level in individuals with the BB genotype was higher than the 25-(OH) vitamin D3 level in individuals with the Bb and bb genotype. A statistically significant difference was found between the groups in terms of the genotype and allele distributions of BsmI polymorphism. When the genotypes were analyzed in terms of bb versus Bb + BB, a statistically significant difference was found between the groups. However, this finding was not found between the intensive care inpatient subgroup and the other inpatient subgroup. In conclusion, BsmI b allele and bb genotype were associated with hospitalization for SARS-COV-2 infection. This may be because individuals with b allele have low levels of vitamin D.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770.2023.2253281