Neural symphony of risky decision making in children with ADHD: Insights from transcranial alternating current stimulation and cognitive modeling

• Published in: Neurophysiologie clinique 2023-10, Vol.53 (5), p.102898-102898, Article 102898
• Main Authors: Nejati, Vahid, Famininejad, Zahra, Rad, Jamal Amani
• Format: Article
• Language: English
• Subjects: Attention deficit-hyperactivity disorder (ADHD); Dorsolateral prefrontal cortex (dlPFC); Risky decision making; Transcranial alternating current stimulation (tACS); Ventromedial prefrontal cortex (vmPFC)
• ISSN: 0987-7053; 1769-7131
• DOI: 10.1016/j.neucli.2023.102898

The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are key brain regions involved in risky decision making, affected in individuals with attention deficit hyperactivity disorder (ADHD). This study aims to examine how entrainment of these areas impacts the process and outcome of risky decision making in children with ADHD. Eighteen children with ADHD performed the balloon analogue risk-taking task (BART) during five different sessions of tACS (1.5 mA, 6 Hz), separated by one-week intervals, via (1) two channels with synchronized stimulation over the left dlPFC and right vmPFC, (2) the same electrode placement with anti-phase stimulation, (3) stimulation over the left dlPFC only, (4) stimulation over right vmPFC only, and (5) sham stimulation. Four-parameter and constant-sensitivity models were used to model the data. The study showed that synchronized stimulation was associated with a reduction in positive prior belief, risk propensity, and deterministic selection. Desynchronized stimulation was associated with accelerated learning from initial selections. Isolated stimulation of the dlPFC leads to riskier decision enhanced learning updates and risk propensity, whereas isolated stimulation of the vmPFC facilitated faster learning and increased probabilistic selection. The results highlight the important roles of the dlPFC and vmPFC and their communication in decision making, showcasing their impact on various aspects of the decision-making process. The findings provide valuable insights into the complex interplay between cognitive and emotional factors in shaping our choices.