Alterations of materno-placento-fetal glucose homeostasis after a single course of antenatal betamethasone

Intrauterine growth impairment is associated with long-term metabolic changes (perinatal programming). We recently demonstrated that antenatal betamethasone (BET) decreased head circumference in term born females. Since glucose is the main energy source for fetal growth, BET-induced changes in mater...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2023-10, Vol.142, p.64-74
Main Authors: Hardt, Anne-Katrin, Braun Tavares, Franziska, Ehrlich, Loreen, Henrich, Wolfgang, Plagemann, Andreas, Braun, Thorsten
Format: Article
Language:English
Subjects:
Betamethasone
Glucose homeostasis
Glucose transporters
Insulin resistance
Insulin-like growth factors
Perinatal programming
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Summary:Intrauterine growth impairment is associated with long-term metabolic changes (perinatal programming). We recently demonstrated that antenatal betamethasone (BET) decreased head circumference in term born females. Since glucose is the main energy source for fetal growth, BET-induced changes in maternal glucose homeostasis, a reduced transplacental glucose transfer or an altered fetal glucose utilization may be linked with the observed growth impairment. 86 pregnant women exposed to BET (single course,
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2023.07.295