MXene/zinc ion embedded agar/sodium alginate hydrogel for rapid and efficient sterilization with photothermal and chemical synergetic therapy

• Published in: Talanta (Oxford) 2024-01, Vol.266 (Pt 2), p.125101, Article 125101
• Main Authors: Hu, Yuwei, Zeng, Qin, Hu, Yifan, He, Jinyun, Wang, Heye, Deng, Chunyan, Li, Dai
• Format: Article
• Language: English
• Subjects: Agar/sodium alginate hydrogel; Antibacterial photothermal therapy; Sterilization treatment; Ti3C2Tx MXene; Wound dressing
• ISSN: 0039-9140; 1873-3573; 1873-3573
• DOI: 10.1016/j.talanta.2023.125101

Bacterial infections can significantly impair wound healing. Therefore, it is essential to develop wound dressings with high antimicrobial activity. Hydrogels are often used as wound dressings due to their excellent physicochemical properties. Herein, by cross linking sodium alginate (SA), agar (AG) with Ti3C2Tx MXene and Zinc ions (Zn2+), a biosafe composite hydrogel (MSG-Zn2+) was developed for fast and efficient sterilization treatment. The excellent photothermal properties of Ti3C2Tx MXene and the chemical antimicrobial activity of Zn2+ enable synergistic photothermal therapy (PTT)/chemical therapy in NIR biowindow with reduced power density and improved antimicrobial efficiency. More importantly, the incorporation of Zn2+ can enhance the effective contact between the hydrogel and bacteria, benefiting both photothermal and chemical antibacteria. In vitro antibacterial experiments showed that MSG-Zn2+ has a broad-spectrum antibacterial effect against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). Cellular experiments showed that the hydrogel had excellent biocompatibility and the released Zn2+ stimulated cell migration. In addition, the prepared MSG-Zn2+ hydrogel has other advantages such as hydrophilic, high swelling, simple and low cost preparation, which meets the requirements of an economical wound dressing. This proposed work shows that this composite hydrogel MSG-Zn2+ has great potential for practical antimicrobial wound dressing applications. [Display omitted] •Rapid and efficient sterilization was achieved based on the MXene/Zinc ion embedded hydrogel.•The MXene/Zinc ion embedded hydrogel possesses the photothermal and chemical synergistic therapy.•The hydrogel has excellent cell migration promoting ability.•The hydrogel has advantages such as hydrophilic, high swelling, simple and low cost preparation.•This MSG-Zn2+ hydrogel is potential for practical antimicrobial wound dressing applications.