The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study

• Published in: Neurophysiologie clinique 2023-10, Vol.53 (5), p.102893-102893, Article 102893
• Main Authors: Kurt Gok, Duygu, İsmailogullari, Sevda, Aldemir, Ramazan, Tokmakci, Mahmut, Firat, Sedat Tarik, Karaca, Zuleyha, Kelestimur, Fahrettin, Zararsiz, Gokmen
• Format: Article
• Language: English
• Subjects: Adrenocorticotropic hormone; Cortisol; Cushing syndrome; Sleep electroencephalogram; Spectral analysis
• ISSN: 0987-7053; 1769-7131
• DOI: 10.1016/j.neucli.2023.102893

Our aim was to investigate the effects of endogenous chronic hypercortisolism on sleep electroencephalogram (EEG) and differences between the adrenocorticotropic hormone (ACTH)-dependent and independent Cushing Syndrome (CS) patients through a sleep spectral analysis program. A total of 32 patients diagnosed as having endogenous CS (12 ACTH-dependent and 20 ACTH-independent) and a control group comprising 16 healthy individuals were included in the study. Polysomnographic analysis was performed. Blood samples were collected at 08:00 AM for analysis of ACTH and basal cortisol, and at 00:00 AM for midnight cortisol levels. The frequency and power of the slow wave activity (SWA), theta, alpha, and beta waves of the first and last non-rapid eye movement (NREM) cycles were measured with a spectral analysis program. The CS patient group had higher SWA power, especially in the first NREM cycle. In the ACTH-dependent group, SWA maximum and mean power values were higher in the frontal channels in the first NREM, compared to the last NREM sleep stage (p