Biomedical applications of electrospun polycaprolactone-based carbohydrate polymers: A review

• Published in: International journal of biological macromolecules 2023-12, Vol.253, p.126642-126642, Article 126642
• Main Authors: Rahimkhoei, Vahid, Padervand, Mohsen, Hedayat, Mohaddeseh, Seidi, Farzad, Dawi, E.A., Akbari, Ali
• Format: Article
• Language: English
• Subjects: Biomedical applications; Electrospin; Polycaprolactone; Polysaccharide
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2023.126642

Carbohydrate used in biomedical applications is influenced by numerous factors. One of the most appealing characteristic of carbohydrates is their ability to reproduce from natural resources which makes them ecologically friendly. Due to their abundance, biocompatibility, and no contamination by residual initiators, the desire for polysaccharides in medical uses is growing. Research on fiber-based materials, with a variety of medical applications including bio-functional scaffolds, continues to yield novel and intriguing findings. Almost all biopolymers of diverse structural compositions are electrospun to fulfill biomedical usage criteria, and the electrospinning technique is widely employed in biomedical technologies for both in-vivo and in-vitro therapies. Due to its biocompatibility and biodegradability, polycaprolactone (PCL) is employed in medical applications like tissue engineering and drug delivery. Although PCL nanofibers have established effects in vitro, more research is needed before their potential therapeutic application in the clinic. Here we tried to focus mainly on the carbohydrate incorporated PCL-based nanofibers production techniques, structures, morphology, and physicochemical properties along with their usage in biomedicine.