Study of terbium production from enriched Gd targets via the reaction 155Gd(d,2n)155Tb

• Published in: Applied radiation and isotopes 2023-11, Vol.201, p.110996-110996, Article 110996
• Main Authors: Wang, Yizheng, Sounalet, Thomas, Guertin, Arnaud, Nigron, Etienne, Michel, Nathalie, Haddad, Férid
• Format: Article
• Language: English
• Subjects: Cross-section measurement; Cyclotron-produced radionuclide; Deuteron irradiation; Enriched gadolinium target; Terbium production; Theranostics radioisotope
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2023.110996

The terbium (Tb) family has attracted much attention in recent years thanks to the diagnostic and therapeutic applications of the quadruplet 149Tb, 152Tb, 155Tb and 161Tb. However, the scarce availability of Tb radioisotopes is one of the main reasons hindering its clinical applications. To increase its availability, this work proposes to use enriched gadolinium (Gd) targets to produce some Tb radioisotopes (149Tb, 152Tb, and 155Tb) via deuteron-induced reactions in cyclotrons. The production of the Auger and gamma emitter 155Tb was chosen as a case study because the 155Gd enrichment (92.8%) is the highest available from all Gd stable isotopes. The involved reaction is 155Gd(d,2n)155Tb. Using enriched thin Gd-containing targets, cross-sections of the reactions 155Gd(d,x)153,154,155,156Tb have been measured at the GIP ARRONAX cyclotron facility with a beam energy ranging from 8 MeV to 30 MeV. This measurement allows for estimating the production yield and the purity of 155Tb, and for determining the irradiation parameters for large production batches. A thick enriched 155Gd2O3 target has been then irradiated with an incident energy of 15.1 MeV and a beam current of 368 nA for 1 h. The production yield of 155Tb is 10.2 MBq/μA/h at End Of Bombardment (EOB) and the purity is 89% after 14 days of decay. These experimental values are consistent with estimation based on measured cross-sections. A comparison of the deuteron-induced and proton-induced production routes is also presented in this paper. •Production of terbium isotopes through deuteron-induced reactions in cyclotrons.•Cross-section measurements of terbium isotopes by enriched 155Gd targets.•Simulation of 155Tb production yield and purity with energy from 8 MeV to 30 MeV.•Experimental study of 155Tb yield and purity by irradiating a thick 155Gd target.•Deuteron-induced reactions are more productive than proton-induced reactions.