Low placental weight may be involved in the etiology of congenital cryptorchidism in neonatal boys

• Published in: European journal of obstetrics & gynecology and reproductive biology 2023-10, Vol.289, p.136-139
• Main Authors: Igata, Yuhei, Sakemi, Yoshihiro, Fujikawa, Ryota, Nakashima, Toshinori, Yamashita, Hironori, Sugino, Noriko, Shono, Takeshi
• Format: Article
• Language: English
• Subjects: Cryptorchidism; Low placental weight; NICU
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2023.08.378

•We evaluated the clinical characteristics of cryptorchidism using the NICU database.•A total of 7882 male neonates were analyzed in this study.•A low placental weight was associated with the development of cryptorchidism. Several factors have been reported to be associated with the etiology of cryptorchidism; however, clear evidence regarding the risk factors for cryptorchidism is elusive. In the present study, we evaluated the clinical characteristics of cryptorchidism using the common neonatal intensive-care unit (NICU) database of the National Hospital Organization and explored one of possible factors associated with the development of cryptorchidism. A total of 7882 male neonates were included in this study. We separated them into two groups: those without cryptorchidism (n = 7852) and those with cryptorchidism (n = 30) at the time of discharge from the NICU. Cryptorchidism was defined as a condition in which the testis was located out of the scrotum on the route of descent at the time of NICU discharge. The associations between cryptorchidism and the maternal, placental, and neonatal information were analyzed. Analyses were performed statistically to compare nominal variables between the groups using Fisher's direct establishment calculation method and logistic regression analyses. Univariate analyses showed the placental weight