High-risk human papillomavirus distribution in different cytological classification women

• Published in: Microbes and infection 2023-11, Vol.25 (8), p.105214, Article 105214
• Main Authors: Zheng, Li-li, Zheng, Li-yuan, Chen, Chao, Wang, Yi-ting, Chen, Shuang-feng, Zhong, Qian-qian, Zhang, Yan, Li, Xue
• Format: Article
• Language: English
• Subjects: Cervical cancer; Early Detection of Cancer; Female; Genotype; Gynecological cancer; HPV DNA genotyping; HPV E6/E7 mRNA testing; Human papillomavirus; Human papillomavirus 16 - genetics; Human papillomavirus 18 - genetics; Humans; Papillomaviridae - genetics; Papillomavirus Infections - diagnosis; Papillomavirus Infections - epidemiology; Retrospective Studies; Uterine Cervical Dysplasia - diagnosis; Uterine Cervical Dysplasia - pathology; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - pathology
• ISSN: 1286-4579; 1769-714X; 1769-714X
• DOI: 10.1016/j.micinf.2023.105214

High-risk human papillomavirus (HR-HPV) infection is a major cause of infection-related cancer worldwide. 3101 HR-HPV-positive females were retrospectively analyzed and grouped using the cervical cytological screening (ThinPrep cytological test, TCT) evaluations combined with colposcopy. The HPV16 infection rate is the highest in all groups. HPV16 was the most frequent in each group, with significant differences between the four groups (χ2 = 23.41, P = 0.0001). The distribution of HPV16 and HPV33 correlated with the pathologic stage in each group. The mixed infection rate of mRNA testing differs significantly between groups (P