The value of plasma presepsin as a diagnostic and prognostic biomarker for sepsis in Southern China

Background Presepsin is a soluble CD14 subtype that has been considered as a novel marker for patients with sepsis. This study explored the clinical value of presepsin for sepsis in Southern China, and further established models for diagnosis and prognosis of sepsis through using machine learning (M...

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Bibliographic Details
Published in:Inflammation research 2023-09, Vol.72 (9), p.1829-1837
Main Authors: Wu, Juehui, Zhan, Xiaoxia, Wang, Songzi, Liao, Xuanren, Li, Laisheng, Luo, Jinmei
Format: Article
Language:English
Subjects:
Allergology
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood culture
CD14 antigen
Chemiluminescence
Coagulation
Dermatology
Diagnosis
Diagnostic systems
Enzyme immunoassay
Immunoassay
Immunology
Inflammation
Learning algorithms
Machine learning
Mathematical models
Mortality
Mortality risk
Neurology
Original Research Paper
Parameters
Performance evaluation
Pharmacology/Toxicology
Prognosis
Renal function
Rheumatology
Sepsis
Septic shock
Urea
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Summary:Background Presepsin is a soluble CD14 subtype that has been considered as a novel marker for patients with sepsis. This study explored the clinical value of presepsin for sepsis in Southern China, and further established models for diagnosis and prognosis of sepsis through using machine learning (ML), by combining presepsin and other laboratory parameters. Methods 269 subjects (105 infected patients, 164 sepsis and septic shock) and 198 healthy controls were enrolled. Laboratory parameters (hematological parameters, coagulation parameters, liver function indices, renal function indices, and inflammatory markers) were collected. Plasma presepsin was tested by chemiluminescence enzyme immunoassay. ML of DxAI™ Research platform was used to establish diagnostic and prognostic models. Sensitivity, specificity, and other performance indicators were used to evaluate the performance of each model. Results The level of presepsin was obviously increased in sepsis and sepsis shock, compared with that of infected and healthy group (all P  
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-023-01787-z