The bending rigidity of phospholipid monolayers in presence of an antimicrobial frog peptide studied by X-ray grazing incidence diffraction

Peptide secretion by living organisms constitutes an integral response process exploited by natural immune systems. In this work we present a model study and insight into this process reporting the thermodynamic and structural effects induced in phospholipid monolayers due to peptide insertion into...

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Bibliographic Details
Published in:Physica. B, Condensed matter Condensed matter, 2005-02, Vol.357 (1), p.185-189
Main Authors: Konovalov, O., O’Flaherty, S.M., Saint-Martin, E., Deutsch, G., Sevcsik, E., Lohner, K.
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Bending rigidity
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General and theoretical biochemistry
Grazing-incidence diffuse X-ray scattering
Langmuir layer
Lipid-peptide interaction
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Summary:Peptide secretion by living organisms constitutes an integral response process exploited by natural immune systems. In this work we present a model study and insight into this process reporting the thermodynamic and structural effects induced in phospholipid monolayers due to peptide insertion into the layer. Synchrotron X-ray radiation is combined with the Langmuir technique and exploited to form ‘lipid–peptide’ monolayers and probe the physical characteristics of the fundamental biological process of ‘peptide secretion’. Our experiments show that the insertion of peptides in the phospholipid layer has adverse effects on the elastic properties of the layer manifested through the bending rigidity.
ISSN:0921-4526
1873-2135
DOI:10.1016/j.physb.2004.11.053