Synthesis, Acid-Base Properties and Preliminary Cell Compatibility Evaluation of Amphoteric Poly(Amido-Hydrazine)s

Amphoteric poly(amido-hydrazine)s (PAHYs) were obtained by hydrogen-transfer polyaddition of hydrazine, 1,2-dimethylhydrazine and 1,1-dimethylhydrazine to 2,2-bisacrylamidoacetic acid. These polymers were studied for biomedical applications, such as degradability in water solution, acid-base propert...

Full description

Saved in:
Bibliographic Details
Published in:Journal of bioactive and compatible polymers 2005-07, Vol.20 (4), p.377-394
Main Authors: Malgesini, Beatrice, Ferruti, Paolo, Manfredi, Amedea, Casolaro, Mario, Chiellini, Federica
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amphoteric poly(amido-hydrazine)s (PAHYs) were obtained by hydrogen-transfer polyaddition of hydrazine, 1,2-dimethylhydrazine and 1,1-dimethylhydrazine to 2,2-bisacrylamidoacetic acid. These polymers were studied for biomedical applications, such as degradability in water solution, acid-base properties, and cell toxicity. They degraded rapidly in aqueous media under physiological conditions, their molecular weight was reduced to about one-fourth, that of the original polymer in less than two days. They exhibited a typical polyelectrolyte behavior with isoelectric points between 4 and 5 and are prevailingly anionic in the blood. In preliminary cell toxicity essays they proved to be remarkably biocompatible, comparable in this respect to amphoteric poly(amido-amine)s (PAAs), and much less toxic than poly-L-lysine and polyethylenimine.
ISSN:0883-9115
1530-8030
DOI:10.1177/0883911505055373