Delta variant neutralizing antibody response following maternal COVID-19 vaccination

The Delta pandemic wave saw increased maternal morbidity and mortality compared to prior viral strains. COVID-19 vaccination in pregnancy elicits detectable levels of neutralizing antibodies to SARS-CoV-2 wild type and SARS-CoV-2 Delta variants in both maternal and neonatal samples at delivery. Our...

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Bibliographic Details
Published in:American journal of infection control 2024-02, Vol.52 (2), p.252-254
Main Authors: Craig, Amanda M., Pavon, Carolina G., Byrd, Alliyah, Weaver, Kristin, Swamy, Geeta K., Fouda, Genevieve, Hughes, Brenna L.
Format: Article
Language:English
Subjects:
Antibodies, Neutralizing
Antibodies, Viral
COVID-19 - prevention & control
COVID-19 Vaccines
Female
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious - prevention & control
SARS-CoV-2
Vaccination
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Summary:The Delta pandemic wave saw increased maternal morbidity and mortality compared to prior viral strains. COVID-19 vaccination in pregnancy elicits detectable levels of neutralizing antibodies to SARS-CoV-2 wild type and SARS-CoV-2 Delta variants in both maternal and neonatal samples at delivery. Our results demonstrate the effectiveness of vaccination which confers an immunological response against newer, and potentially more dangerous, viral variants. •All vaccinated individuals had neutralizing antibodies to SARS-CoV-2 wild type.•Most vaccinated individuals had neutralizing antibodies to SARS-CoV-2 Delta variant.•Neutralizing antibodies present in both maternal and neonatal blood at delivery.•COVID-19 vaccination provides maternal protection and passive neonatal immunity.
ISSN:0196-6553
1527-3296
1527-3296
DOI:10.1016/j.ajic.2023.09.002