Dynamic plasmid copy number control for synthetic biology

Plasmids that replicate independently from chromosomes are valuable genetic tools for biological research. Dynamic control of plasmid copy number facilitates flexible regulation of the gene of interest or the genetic circuit installed in the plasmid. This useful strategy is being integrated into syn...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2024-02, Vol.42 (2), p.147-150
Main Authors: Wang, Gege, Wang, Qi, Qi, Qingsheng, Wang, Qian
Format: Article
Language:English
Subjects:
Biological research
Biology
biosensor
Biosensors
Biosynthesis
Cell division
Chromosomes
Circuits
Cloning
Copy number
Copy number control
DNA Copy Number Variations
Dynamic control
Enzymes
Gene expression
Genomes
Gram-positive bacteria
metabolic reprogramming
Metabolism
Mutation
plasmid copy number
plasmid replication regulation machinery
Plasmids
Plasmids - genetics
Proteins
Ribonucleic acid
RNA
Synthetic Biology
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Summary:Plasmids that replicate independently from chromosomes are valuable genetic tools for biological research. Dynamic control of plasmid copy number facilitates flexible regulation of the gene of interest or the genetic circuit installed in the plasmid. This useful strategy is being integrated into synthetic biology for metabolic reprogramming and biosensing applications. Plasmids that replicate independently from chromosomes are valuable genetic tools for biological research. Dynamic control of plasmid copy number facilitates flexible regulation of the gene of interest or the genetic circuit installed in the plasmid. This useful strategy is being integrated into synthetic biology for metabolic reprogramming and biosensing applications.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2023.08.004