Optimizing congenital cytomegalovirus detection by pool testing in saliva by a rapid molecular test

Universal congenital cytomegalovirus (cCMV) screening in saliva is increasingly recommended. The aim of our study was to correlate the performance of a point-of-care rapid molecular test with CMV real time PCR (CMV RT-PCR) detection, using saliva pool-testing in newborns under a universal screening...

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Bibliographic Details
Published in:European journal of pediatrics 2023-11, Vol.182 (11), p.5131-5136
Main Authors: Izquierdo, Giannina, Farfan, Mauricio J, Villavicencio, Leonel, Montecinos, Luisa, Tarque, Felipe, Acevedo, William, Reyes, Roberto, Guerra, Carolina, Araya, Leslie, Sepúlveda, Belén, Cabrera, Camila, Medina, Pamela, Mendez, Jocelyn, Mardones, Elieder, Torres, Juan P
Format: Article
Language:English
Subjects:
Congenital infection
Cost analysis
Cytomegalovirus
Cytomegalovirus - genetics
Cytomegalovirus Infections - diagnosis
Hearing loss
Humans
Infant
Infant, Newborn
Medicine
Medicine & Public Health
Neonatal Screening - methods
Neonates
Pediatrics
Polymerase chain reaction
Real-Time Polymerase Chain Reaction - methods
Saliva
Urine
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Summary:Universal congenital cytomegalovirus (cCMV) screening in saliva is increasingly recommended. The aim of our study was to correlate the performance of a point-of-care rapid molecular test with CMV real time PCR (CMV RT-PCR) detection, using saliva pool-testing in newborns under a universal screening strategy. Saliva swabs were prospectively collected from newborns 
ISSN:1432-1076
0340-6199
1432-1076
DOI:10.1007/s00431-023-05183-x