Implantable bioelectronic systems for early detection of kidney transplant rejection

Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur infrequently and are risky, and measuring biomarker levels in blood can lead to false-negative and -positive outcomes. We developed an implantable bioelectronic system capable of continuous, real-time, lon...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2023-09, Vol.381 (6662), p.1105-1112
Main Authors: Madhvapathy, Surabhi R, Wang, Jiao-Jing, Wang, Heling, Patel, Manish, Chang, Anthony, Zheng, Xin, Huang, Yonggang, Zhang, Zheng J, Gallon, Lorenzo, Rogers, John A
Format: Article
Language:English
Subjects:
Allografts
Animal models
Animals
Bioelectricity
Early Diagnosis
Graft rejection
Graft Rejection - diagnosis
Kidney
Kidney Diseases
Kidney Transplantation
Kidney transplants
Kidneys
Monitoring, Physiologic - instrumentation
Postoperative Complications
Rats
Rejection
Renal failure
Thermal conductivity
Transplantation
Wireless Technology - instrumentation
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Summary:Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur infrequently and are risky, and measuring biomarker levels in blood can lead to false-negative and -positive outcomes. We developed an implantable bioelectronic system capable of continuous, real-time, long-term monitoring of the local temperature and thermal conductivity of a kidney for detecting inflammatory processes associated with graft rejection, as demonstrated in rat models. The system detects ultradian rhythms, disruption of the circadian cycle, and/or a rise in kidney temperature. These provide warning signs of acute kidney transplant rejection that precede changes in blood serum creatinine/urea nitrogen by 2 to 3 weeks and approximately 3 days for cases of discontinued and absent administration of immunosuppressive therapy, respectively.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/SCIENCE.ADH7726