Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity

•Single cell transcriptomic analyses showed that DCs and T cells were the main cell types in the MDA samples.•Compared with HPV, MDA had a small number of specific B cells, a large number of DC cells and monocytes, and a large number of T cells.•The infiltration of a large number of immune cells pro...

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Published in:International immunopharmacology 2023-11, Vol.124, p.110907-110907, Article 110907
Main Authors: Zhang, Hui, Liu, Chunhua, Zhai, Xiaoqian, Zhang, Qianqian, Zhou, Yao, Huang, Hu, Ding, Mingde, Shi, Qiang, Liu, Yan, Tang, Ying, Liu, Guanghai, Wang, Hongmei
Format: Article
Language:English
Subjects:
Adenocarcinoma
Dendritic cells
Malignant adenoma
T cells
Uterine cervix
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Summary:•Single cell transcriptomic analyses showed that DCs and T cells were the main cell types in the MDA samples.•Compared with HPV, MDA had a small number of specific B cells, a large number of DC cells and monocytes, and a large number of T cells.•The infiltration of a large number of immune cells provided a new therapeutic strategy for the treatment of MDA patients. Minimal deviation adenocarcinoma (MDA) of the uterine cervix, also referred to as malignant adenoma, is a rare subtype of cervical adenocarcinoma that exhibits histological characteristics resembling those of benign tumors, resulting in a low diagnostic rate and a lack of effective treatment options. The transcriptomic features of MDA at the single-cell resolution and within the tumor microenvironment (TME) remain unclear. In this study, we conducted single-cell transcriptomic analyses of MDA samples (Ca) and adjacent normal tissues (PCa). The present study reveals the prevalence of dendritic cells (DCs) and T cells in the carcinoma (Ca) of mammary ductal adenocarcinoma (MDA), with DCs undergoing significant metabolic reprogramming and immune stress. Additionally, our findings demonstrate the crucial involvement of DCs and T cells in the pathogenesis and metastatic progression of MDA, as evidenced by single-cell transcriptomic profiling of MDA and HPV samples. This resource provides a more profound understanding of the indolent nature of MDA and may prove useful in the development of MDA immunotherapy.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2023.110907