Novel biosynthesis of gold nanoparticles for multifunctional applications: Electrochemical detection of hydrazine and treatment of gastric cancer

• Published in: Environmental research 2023-12, Vol.238, p.117081-117081, Article 117081
• Main Authors: Yan, Kangpeng, Yan, Lan, Kuang, Weihua, Kaffash, Afsaneh, Mahdavi, Behnam, Baghayeri, Mehdi, Liu, Weiwei
• Format: Article
• Language: English
• Subjects: Gastric cancer; Gold nanoparticles; Green synthesis; Hydrazine sensor; Table olive extract
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2023.117081

In this work, an environmentally friendly strategy was used to synthesize gold nanoparticles (Au NPs) using Olea europaea (olive) fruit. Transmission electron microscopy (TEM), UV–Vis spectroscopy, X-ray diffraction (XRD) and energy-dispersive X-ray (EDX) were used to characterize the physicochemical properties of the synthesized NPs. An Au NPs modified glassy carbon electrode was used to investigate the direct electrochemical oxidation of hydrazine. The suggested hydrazine sensor has good performance, such as a wide linear range (2.5–275 μM), low limit of detection (0.09 μM), notable selectivity and excellent reproducibility (RSD = 2.2%). The in-vitro cytotoxicity of three human cancer cell lines (KATOIII, NCI-N87, and SNU-16) was also explored with various concentrations of Au NPs prepared from olive fruit extract. Bio-synthesized Au NPs were found to have cytotoxic properties against gastric cancer in humans based on MTT assay protocol. The obtained results show that green synthesized Au NPs can be successfully employed in electrochemical sensing and cancer treatment applications. [Display omitted] •Au NPs were fabricated with a green approach using the Olea europaea (olive) fruit extract.•High anticancer activity was obtained against KATOIII, NCI-N87, and SNU-16 gastric cancer cells at different concentrations of Au NPs.•The biogenic Au NPs were successfully used to fabricate an effective hydrazine electrochemical sensor.