Effects of Schumann resonance on the proliferation and migration of normal human epidermal keratinocytes and the expression of DEFB1 and SIRT1

Background When the skin is damaged and its barrier function is disrupted, the proliferation and migration of epidermal keratinocytes are vital for repairing the damaged area. The Schumann resonance at 7.8 Hz has been reported to protect rat cardiomyocytes against oxidative stress and inhibit the pr...

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Published in:Journal of cosmetic dermatology 2024-02, Vol.23 (2), p.676-680
Main Authors: Sugiwaki, Hidemi, Kotani, Mayumi, Fujita, Akihito, Moriwaki, Shinichi
Format: Article
Language:English
Subjects:
Animals
beta-Defensins - genetics
beta-Defensins - metabolism
beta-Defensins - pharmacology
Cell adhesion & migration
Cell growth
Cell Proliferation
Cells, Cultured
Dermatitis
Electromagnetism
Epidermis - metabolism
Gene expression
Humans
Keratinocytes - metabolism
Mice
normal human epidermal keratinocytes
Peptides
Rats
Schumann resonance
sirtuin 1
Sirtuin 1 - genetics
Sirtuin 1 - metabolism
Sirtuin 1 - pharmacology
Skin
Skin - metabolism
Statistical analysis
ultra‐low‐frequency waves
β‐Defensin
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container_issue 2
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container_title Journal of cosmetic dermatology
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creator Sugiwaki, Hidemi
Kotani, Mayumi
Fujita, Akihito
Moriwaki, Shinichi
description Background When the skin is damaged and its barrier function is disrupted, the proliferation and migration of epidermal keratinocytes are vital for repairing the damaged area. The Schumann resonance at 7.8 Hz has been reported to protect rat cardiomyocytes against oxidative stress and inhibit the proliferation of B16 mouse melanoma cells. However, its effect on the skin is unknown. Aims In this study, we applied 7.8‐Hz electromagnetic waves to normal human epidermal keratinocytes (NHEKs) and investigated its effects on cell proliferation and migration, β‐defensin (DEFB1) and sirtuin 1 (SIRT1) expression. Methods We performed cell proliferation assay, cell migrationassay and gene expression analysis of DEFB1 and SIRT1. Results We found that the application of 7.8‐Hz electromagnetic waves caused a 2.8‐fold increase in NHEK proliferation, enhanced cell migration, and increased the expression of DEFB1 and SIRT1 by 2.4‐fold and 4.9‐fold, respectively. Conclusions These results suggest that the application of 7.8‐Hz electromagnetic waves may contribute to improving the skin barrier function and skin ulcer.
doi_str_mv 10.1111/jocd.15988
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The Schumann resonance at 7.8 Hz has been reported to protect rat cardiomyocytes against oxidative stress and inhibit the proliferation of B16 mouse melanoma cells. However, its effect on the skin is unknown. Aims In this study, we applied 7.8‐Hz electromagnetic waves to normal human epidermal keratinocytes (NHEKs) and investigated its effects on cell proliferation and migration, β‐defensin (DEFB1) and sirtuin 1 (SIRT1) expression. Methods We performed cell proliferation assay, cell migrationassay and gene expression analysis of DEFB1 and SIRT1. Results We found that the application of 7.8‐Hz electromagnetic waves caused a 2.8‐fold increase in NHEK proliferation, enhanced cell migration, and increased the expression of DEFB1 and SIRT1 by 2.4‐fold and 4.9‐fold, respectively. Conclusions These results suggest that the application of 7.8‐Hz electromagnetic waves may contribute to improving the skin barrier function and skin ulcer.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.15988</identifier><identifier>PMID: 37697693</identifier><language>eng</language><publisher>England: John Wiley &amp; Sons, Inc</publisher><subject>Animals ; beta-Defensins - genetics ; beta-Defensins - metabolism ; beta-Defensins - pharmacology ; Cell adhesion &amp; migration ; Cell growth ; Cell Proliferation ; Cells, Cultured ; Dermatitis ; Electromagnetism ; Epidermis - metabolism ; Gene expression ; Humans ; Keratinocytes - metabolism ; Mice ; normal human epidermal keratinocytes ; Peptides ; Rats ; Schumann resonance ; sirtuin 1 ; Sirtuin 1 - genetics ; Sirtuin 1 - metabolism ; Sirtuin 1 - pharmacology ; Skin ; Skin - metabolism ; Statistical analysis ; ultra‐low‐frequency waves ; β‐Defensin</subject><ispartof>Journal of cosmetic dermatology, 2024-02, Vol.23 (2), p.676-680</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. 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The Schumann resonance at 7.8 Hz has been reported to protect rat cardiomyocytes against oxidative stress and inhibit the proliferation of B16 mouse melanoma cells. However, its effect on the skin is unknown. Aims In this study, we applied 7.8‐Hz electromagnetic waves to normal human epidermal keratinocytes (NHEKs) and investigated its effects on cell proliferation and migration, β‐defensin (DEFB1) and sirtuin 1 (SIRT1) expression. Methods We performed cell proliferation assay, cell migrationassay and gene expression analysis of DEFB1 and SIRT1. Results We found that the application of 7.8‐Hz electromagnetic waves caused a 2.8‐fold increase in NHEK proliferation, enhanced cell migration, and increased the expression of DEFB1 and SIRT1 by 2.4‐fold and 4.9‐fold, respectively. 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The Schumann resonance at 7.8 Hz has been reported to protect rat cardiomyocytes against oxidative stress and inhibit the proliferation of B16 mouse melanoma cells. However, its effect on the skin is unknown. Aims In this study, we applied 7.8‐Hz electromagnetic waves to normal human epidermal keratinocytes (NHEKs) and investigated its effects on cell proliferation and migration, β‐defensin (DEFB1) and sirtuin 1 (SIRT1) expression. Methods We performed cell proliferation assay, cell migrationassay and gene expression analysis of DEFB1 and SIRT1. Results We found that the application of 7.8‐Hz electromagnetic waves caused a 2.8‐fold increase in NHEK proliferation, enhanced cell migration, and increased the expression of DEFB1 and SIRT1 by 2.4‐fold and 4.9‐fold, respectively. 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subjects Animals
beta-Defensins - genetics
beta-Defensins - metabolism
beta-Defensins - pharmacology
Cell adhesion & migration
Cell growth
Cell Proliferation
Cells, Cultured
Dermatitis
Electromagnetism
Epidermis - metabolism
Gene expression
Humans
Keratinocytes - metabolism
Mice
normal human epidermal keratinocytes
Peptides
Rats
Schumann resonance
sirtuin 1
Sirtuin 1 - genetics
Sirtuin 1 - metabolism
Sirtuin 1 - pharmacology
Skin
Skin - metabolism
Statistical analysis
ultra‐low‐frequency waves
β‐Defensin
title Effects of Schumann resonance on the proliferation and migration of normal human epidermal keratinocytes and the expression of DEFB1 and SIRT1
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