Ingestible pH sensing device for gastrointestinal health monitoring based on thread-based electrochemical sensors

There exists a strong correlation between the pH levels of the gastrointestinal (GI) tract and GI diseases such as inflammatory bowel disease (IBS), ulcerative colitis, and pancreatis. Existing methods for diagnosing many GI diseases predominantly rely on invasive, expensive, and time-consuming tech...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2023-10, Vol.190 (10), p.385, Article 385
Main Authors: Asci, Cihan, Sharma, Atul, Del-Rio-Ruiz, Ruben, Sonkusale, Sameer
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biomarkers
Biosensors
Characterization and Evaluation of Materials
Chemical sensors
Chemistry
Chemistry and Materials Science
Circuit boards
Circuit printing
Diameters
Gastrointestinal system
Hydrogen-ion concentration
Irritable bowel syndrome
Microengineering
Modular systems
Nanochemistry
Nanotechnology
Original Paper
Printed circuits
Sensors
Three dimensional printing
Ulcerative colitis
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Summary:There exists a strong correlation between the pH levels of the gastrointestinal (GI) tract and GI diseases such as inflammatory bowel disease (IBS), ulcerative colitis, and pancreatis. Existing methods for diagnosing many GI diseases predominantly rely on invasive, expensive, and time-consuming techniques such as colonoscopy and endoscopy. In this study, an autonomous ingestible smart biosensing system in a pill format with integrated pH sensors is reported. The smart sensing pills will measure the pH profile as they transit through the GI tract. The data is then downloaded from the pills after they are collected from the feces. The sensor is based on electrodeposited PANI on carbon-coated conductive threads providing high pH sensitivity. Engineering innovations allowed integration of thread-based sensors on 3D-printed pill surfaces with front-end readout electronics, memory, and microcontroller assembled on mm-size circular printed circuit boards. The entire smart sensing pill possesses an overall length of 22.1 mm and an outer diameter of 9 mm. The modular biosensing system allows integration of thread-based biosensors to monitor other biomarkers in GI tract that mitigates the complex sensor fabrication process as well as overall pill assembly.
ISSN:0026-3672
1436-5073
1436-5073
DOI:10.1007/s00604-023-05946-1