Genomic associations with antibody response to an oral cholera vaccine

• Published in: Vaccine 2023-10, Vol.41 (42), p.6391-6400
• Main Authors: Roy, Vijay Laxmi, Majumder, Partha P.
• Format: Article
• Language: English
• Subjects: 4p14; 4p16.1; 6q23.3; Anti-lipopolysaccharide antibody response; Antibodies; antibody formation; Antibody response; Autoimmune diseases; Autophagy; Blood groups; blood serum; Cholera; Cholera vaccine; Chronic conditions; Gene clusters; genes; Genetic testing; Genome-wide association studies; Genome-wide association study; Genomes; Genomics; Genotype & phenotype; Helicobacter pylori; Immune response; Immune system; Immunoglobulins; Immunology; Infectious diseases; interleukin-2; Linkage disequilibrium; lupus erythematosus; Multiple sclerosis; NF-κB protein; pandemic; Pandemics; Parasites; Public health; Rheumatoid arthritis; sclerosis; Single-nucleotide polymorphism; Smallpox; Systemic lupus erythematosus; TBC1D1; TBC1D14; TNFAIP3; Vaccines; Vibrio cholerae; Waterborne diseases
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2023.09.016

•Cholera is the longest ongoing pandemic.•A GWAS on antibody response to an oral cholera vaccine was conducted on ∼1000 recipients from India.•Three cluster of SNPs mapped to TBC1D1, TBC1D14 and TNFAIP3 loci were most significantly associated with cholera vaccine response. Oral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst its recipients. We undertook a genome wide association study (GWAS) on antibody response to the cholera vaccine; globally, the first GWAS on cholera vaccine response. We identified three clusters of bi-allelic SNPs, in high within-cluster linkage disequilibrium that were moderately (p