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Melamine exposure during the weaning period negatively affects ovarian reserve
In this study, it was aimed to investigate the effects of melamine exposure since the weaning period on ovarian tissue and ovarian reserve. Melamine is illegally added to milk and formula to provide high false protein positivity. Female rats (the weaning period = 21 days old, n = 18) were divided in...
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| Published in: | Environmental science and pollution research international 2023-10, Vol.30 (47), p.104805-104813 |
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| container_title | Environmental science and pollution research international |
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| creator | Erisgin, Zuleyha Barak, Mensure Zuhal Usta, Murat Tekelioglu, Yavuz Turkoglu, Ismail Mutlu, Hasan Serdar |
| description | In this study, it was aimed to investigate the effects of melamine exposure since the weaning period on ovarian tissue and ovarian reserve. Melamine is illegally added to milk and formula to provide high false protein positivity. Female rats (the weaning period = 21 days old,
n
= 18) were divided into 3 groups. 0.1 mL saline was applied to the control group by gavage for 21 days. Fifty mg/kg and seventy-five mg/kg melamine was dissolved in 0.1 mL of saline and applied by gavage for 21 days, respectively. At the end of the experiment, plasma anti-Mullerian hormone (AMH) was measured, follicle count and ovarian diameter measurement were performed in the right ovaries, and flow cytometric analysis for apoptosis was performed in the left ovaries. While a statistically significant decrease was not observed in the number of the follicle and ovarian diameter between the control and melamine-treated groups (
p
> 0.05), a significant decrease in the corpus luteum and a significant increase in the number of atretic follicles were observed (
p
< 0.05). Apoptosis (Annexin V) increased in both melamine groups and AMH plasma level decreased significantly in the 75 mg/kg group (
p
< 0.05). Melamine exposure from the weaning (early postnatal) period may cause a decrease in ovarian reserve in parallel with a dose increase. |
| doi_str_mv | 10.1007/s11356-023-29752-7 |
| format | article |
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n
= 18) were divided into 3 groups. 0.1 mL saline was applied to the control group by gavage for 21 days. Fifty mg/kg and seventy-five mg/kg melamine was dissolved in 0.1 mL of saline and applied by gavage for 21 days, respectively. At the end of the experiment, plasma anti-Mullerian hormone (AMH) was measured, follicle count and ovarian diameter measurement were performed in the right ovaries, and flow cytometric analysis for apoptosis was performed in the left ovaries. While a statistically significant decrease was not observed in the number of the follicle and ovarian diameter between the control and melamine-treated groups (
p
> 0.05), a significant decrease in the corpus luteum and a significant increase in the number of atretic follicles were observed (
p
< 0.05). Apoptosis (Annexin V) increased in both melamine groups and AMH plasma level decreased significantly in the 75 mg/kg group (
p
< 0.05). Melamine exposure from the weaning (early postnatal) period may cause a decrease in ovarian reserve in parallel with a dose increase.</description><identifier>ISSN: 1614-7499</identifier><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-023-29752-7</identifier><identifier>PMID: 37707728</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Annexin V ; Anti-Mullerian Hormone - metabolism ; Anti-Mullerian Hormone - pharmacology ; Apoptosis ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Corpus luteum ; Diameters ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Exposure ; Female ; Flow cytometry ; Follicles ; Melamine ; Ovarian Follicle ; Ovarian Reserve ; Ovaries ; Ovary ; Rats ; Research Article ; Statistical analysis ; Waste Water Technology ; Water Management ; Water Pollution Control ; Weaning</subject><ispartof>Environmental science and pollution research international, 2023-10, Vol.30 (47), p.104805-104813</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-5e1eca8aadc416610bcab630192ff941c8c0702c7731beb6c960cc9d1d32b8693</cites><orcidid>0000-0003-3523-6542</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2875645759/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2875645759?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,11688,27924,27925,36060,36061,44363,74895</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37707728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erisgin, Zuleyha</creatorcontrib><creatorcontrib>Barak, Mensure Zuhal</creatorcontrib><creatorcontrib>Usta, Murat</creatorcontrib><creatorcontrib>Tekelioglu, Yavuz</creatorcontrib><creatorcontrib>Turkoglu, Ismail</creatorcontrib><creatorcontrib>Mutlu, Hasan Serdar</creatorcontrib><title>Melamine exposure during the weaning period negatively affects ovarian reserve</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>In this study, it was aimed to investigate the effects of melamine exposure since the weaning period on ovarian tissue and ovarian reserve. Melamine is illegally added to milk and formula to provide high false protein positivity. Female rats (the weaning period = 21 days old,
n
= 18) were divided into 3 groups. 0.1 mL saline was applied to the control group by gavage for 21 days. Fifty mg/kg and seventy-five mg/kg melamine was dissolved in 0.1 mL of saline and applied by gavage for 21 days, respectively. At the end of the experiment, plasma anti-Mullerian hormone (AMH) was measured, follicle count and ovarian diameter measurement were performed in the right ovaries, and flow cytometric analysis for apoptosis was performed in the left ovaries. While a statistically significant decrease was not observed in the number of the follicle and ovarian diameter between the control and melamine-treated groups (
p
> 0.05), a significant decrease in the corpus luteum and a significant increase in the number of atretic follicles were observed (
p
< 0.05). Apoptosis (Annexin V) increased in both melamine groups and AMH plasma level decreased significantly in the 75 mg/kg group (
p
< 0.05). Melamine exposure from the weaning (early postnatal) period may cause a decrease in ovarian reserve in parallel with a dose increase.</description><subject>Animals</subject><subject>Annexin V</subject><subject>Anti-Mullerian Hormone - metabolism</subject><subject>Anti-Mullerian Hormone - pharmacology</subject><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Corpus luteum</subject><subject>Diameters</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Exposure</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Follicles</subject><subject>Melamine</subject><subject>Ovarian Follicle</subject><subject>Ovarian Reserve</subject><subject>Ovaries</subject><subject>Ovary</subject><subject>Rats</subject><subject>Research Article</subject><subject>Statistical analysis</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Weaning</subject><issn>1614-7499</issn><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyyQJTZsAn4kdrxEFS-pwAbWluNMSqq8sJNC_56ElIdYsJpZnHtndBA6puScEiIvPKU8EgFhPGBKRiyQO2hKBQ0DGSq1-2ufoAPvV4QwopjcRxMuJZGSxVP0cA-FKfMKMLw3te8c4LRzebXE7QvgNzDVsDfg8jrFFSxNm6-h2GCTZWBbj-u1cbmpsAMPbg2HaC8zhYej7Zyh5-urp_ltsHi8uZtfLgLLmWiDCChYExuT2pAKQUliTSI4oYplmQqpjS2RhFkpOU0gEVYJYq1KacpZEgvFZ-hs7G1c_dqBb3WZewtFYSqoO69ZLMJYiSge0NM_6KruXNV_11MyEmEko4FiI2Vd7b2DTDcuL43baEr0YFuPtnVvW3_a1rIPnWyru6SE9DvypbcH-Aj4ZnAK7uf2P7UfbTeK0g</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Erisgin, Zuleyha</creator><creator>Barak, Mensure Zuhal</creator><creator>Usta, Murat</creator><creator>Tekelioglu, Yavuz</creator><creator>Turkoglu, Ismail</creator><creator>Mutlu, Hasan Serdar</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3523-6542</orcidid></search><sort><creationdate>20231001</creationdate><title>Melamine exposure during the weaning period negatively affects ovarian reserve</title><author>Erisgin, Zuleyha ; Barak, Mensure Zuhal ; Usta, Murat ; Tekelioglu, Yavuz ; Turkoglu, Ismail ; Mutlu, Hasan Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-5e1eca8aadc416610bcab630192ff941c8c0702c7731beb6c960cc9d1d32b8693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Annexin V</topic><topic>Anti-Mullerian Hormone - 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Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erisgin, Zuleyha</au><au>Barak, Mensure Zuhal</au><au>Usta, Murat</au><au>Tekelioglu, Yavuz</au><au>Turkoglu, Ismail</au><au>Mutlu, Hasan Serdar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melamine exposure during the weaning period negatively affects ovarian reserve</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>30</volume><issue>47</issue><spage>104805</spage><epage>104813</epage><pages>104805-104813</pages><issn>1614-7499</issn><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>In this study, it was aimed to investigate the effects of melamine exposure since the weaning period on ovarian tissue and ovarian reserve. Melamine is illegally added to milk and formula to provide high false protein positivity. Female rats (the weaning period = 21 days old,
n
= 18) were divided into 3 groups. 0.1 mL saline was applied to the control group by gavage for 21 days. Fifty mg/kg and seventy-five mg/kg melamine was dissolved in 0.1 mL of saline and applied by gavage for 21 days, respectively. At the end of the experiment, plasma anti-Mullerian hormone (AMH) was measured, follicle count and ovarian diameter measurement were performed in the right ovaries, and flow cytometric analysis for apoptosis was performed in the left ovaries. While a statistically significant decrease was not observed in the number of the follicle and ovarian diameter between the control and melamine-treated groups (
p
> 0.05), a significant decrease in the corpus luteum and a significant increase in the number of atretic follicles were observed (
p
< 0.05). Apoptosis (Annexin V) increased in both melamine groups and AMH plasma level decreased significantly in the 75 mg/kg group (
p
< 0.05). Melamine exposure from the weaning (early postnatal) period may cause a decrease in ovarian reserve in parallel with a dose increase.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37707728</pmid><doi>10.1007/s11356-023-29752-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3523-6542</orcidid></addata></record> |
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| identifier | ISSN: 1614-7499 |
| ispartof | Environmental science and pollution research international, 2023-10, Vol.30 (47), p.104805-104813 |
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| language | eng |
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| source | ABI/INFORM Global; Springer Nature |
| subjects | Animals Annexin V Anti-Mullerian Hormone - metabolism Anti-Mullerian Hormone - pharmacology Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Corpus luteum Diameters Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Exposure Female Flow cytometry Follicles Melamine Ovarian Follicle Ovarian Reserve Ovaries Ovary Rats Research Article Statistical analysis Waste Water Technology Water Management Water Pollution Control Weaning |
| title | Melamine exposure during the weaning period negatively affects ovarian reserve |
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