A universe of second messengers for cGLR-STING signaling

• Published in: Immunity (Cambridge, Mass.) Mass.), 2023-09, Vol.56 (9), p.1975-1977
• Main Authors: Wei, Xubiao, Zhang, Conggang
• Format: Article
• Language: English
• Subjects: Animals; Drosophila; Drosophila melanogaster; Second Messenger Systems; Signal Transduction
• ISSN: 1074-7613; 1097-4180; 1097-4180
• DOI: 10.1016/j.immuni.2023.08.017

2′3′-cyclic GMP-AMP (2′3′-cGAMP) and 3′2′-cGAMP activate STING-dependent antiviral immunity in Drosophila melanogaster but fail to control infection by C virus in some fly species. In this issue of Immunity, Cai et al. reveal that Drosophila produces multiple cyclic di-nucleotides (CDNs) in response to viral infection. One of these CDNs—2′3′-c-di-GMP—is a very potent STING activator capable of promoting antiviral immunity in otherwise susceptible flies. 2′3′-cyclic GMP-AMP (2′3′-cGAMP) and 3′2′-cGAMP activate STING-dependent antiviral immunity in Drosophila melanogaster but fail to control infection by C virus in some fly species. In this issue of Immunity, Cai et al. reveal that Drosophila produces multiple cyclic di-nucleotides in response to viral infection. One of these CDNs—2′3′-c-di-GMP—is a very potent STING activator capable of promoting antiviral immunity in otherwise susceptible flies.