Synergistic extraction of nucleobases by the combination of calixarene and D2EHPA

A calix[6]arene carboxylic acid derivative incorporating tert-octyl groups at the upper rim was found to be soluble in an aliphatic organic solvent. The extraction behavior of various nucleobases was investigated with the calix[6]arene carboxylic acid derivative. In an isooctane system, neither cali...

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Published in:Separation and purification technology 2005-07, Vol.44 (2), p.175-180
Main Authors: Shimojo, Kojiro, Goto, Masahiro
Format: Article
Language:English
Subjects:
Applied sciences
Calixarene
Chemical engineering
Exact sciences and technology
Liquid-liquid extraction
Molecular recognition
Nucleobase
Solvent extraction
Synergistic effect
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description A calix[6]arene carboxylic acid derivative incorporating tert-octyl groups at the upper rim was found to be soluble in an aliphatic organic solvent. The extraction behavior of various nucleobases was investigated with the calix[6]arene carboxylic acid derivative. In an isooctane system, neither calix[6]arene nor D2EHPA were very effective at nucleobase extraction. However, addition of D2EHPA along with calix[6]arene drastically enhanced the efficiency of adenine and cytosine extraction. It was found that D2EHPA is a powerful synergistic reagent with calix[6]arene for adenine extraction. It was demonstrated that one nucleobases forms a stable complex with one calix[6]arene and two D2EHPA molecules, based on Job's method. Adenine was recovered from the organic phase by contacting with a fresh acidic solution.
doi_str_mv 10.1016/j.seppur.2005.01.006
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subjects Applied sciences
Calixarene
Chemical engineering
Exact sciences and technology
Liquid-liquid extraction
Molecular recognition
Nucleobase
Solvent extraction
Synergistic effect
title Synergistic extraction of nucleobases by the combination of calixarene and D2EHPA
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