Home systolic blood pressure time in therapeutic range and cardiovascular risk: the practitioner-based nationwide J-HOP study extended

• Published in: Hypertension research 2024-01, Vol.47 (1), p.112-119
• Main Authors: Kario, Kazuomi, Tomitani, Naoko, Okawara, Yukie, Kanegae, Hiroshi, Hoshide, Satoshi
• Format: Article
• Language: English
• Subjects: Aged; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases - complications; Cardiovascular Diseases - etiology; Heart Disease Risk Factors; Humans; Hypertension - complications; Hypertension - drug therapy; Hypertension - epidemiology; Risk Factors; Stroke
• ISSN: 0916-9636; 1348-4214; 1348-4214
• DOI: 10.1038/s41440-023-01416-6

Time in therapeutic range (TTR) for office systolic blood pressure (SBP) is an independent predictor of major cardiovascular events. However, the clinical implications of TTR for home SBP have not yet been investigated. This study determined the association between TTR of home SBP and cardiovascular events in individuals with ≥1 cardiovascular risk factor who were enrolled in The Japan Morning Surge-Home Blood Pressure (J-HOP) study. The therapeutic range for home SBP was defined as home SBP of 100-135 mmHg during the 13-day baseline period of the J-HOP study. Participants were divided into subgroups based on quartiles of TTR for home SBP, and the risk of cardiovascular events was determined in each quartile. During a mean 6.3 years of follow-up in 4070 participants (mean age 65 years), cardiovascular events included stroke in 92, coronary artery disease in 119, heart failure in 41 and aortic dissection in 8. The adjusted hazard ratio (95% confidence interval) for the risk of total cardiovascular events in participants with home SBP TTR in the lowest (100%) versus highest quartile (