Navigating T cell brain entry in MS

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is driven by autoreactive lymphocytes. An in vivo CRISPR screen of T cell infiltration in a rat model of MS now identifies the genetic modules that control this key step in the immunopathology of MS.

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Bibliographic Details
Published in:Nature neuroscience 2023-10, Vol.26 (10), p.1661-1662
Main Authors: Ali, Magda, Liston, Adrian
Format: Article
Language:English
Subjects:
631/378/1341
631/378/1689/1666
631/378/371
Animal Genetics and Genomics
Autoimmune diseases
Bar codes
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cell adhesion & migration
Central nervous system
Cerebrospinal fluid
Cloning
CRISPR
Disease
Genes
Genomes
Hypotheses
Lymphocytes
Lymphocytes T
Multiple sclerosis
Neurobiology
Neurosciences
News & Views
news-and-views
Patients
Rodents
Spinal cord
T cell receptors
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Description
Summary:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is driven by autoreactive lymphocytes. An in vivo CRISPR screen of T cell infiltration in a rat model of MS now identifies the genetic modules that control this key step in the immunopathology of MS.
ISSN:1097-6256
1546-1726
1546-1726
DOI:10.1038/s41593-023-01433-1