Performance of Hippocampal Radiomics Models Based on T2-FLAIR Images in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

• Published in: European journal of radiology 2023-10, Vol.167, p.111082, Article 111082
• Main Authors: Wang, Xiaoyu, Luo, Xiaoting, Pan, Haitao, Wang, Xiaoyang, Xu, Shangwen, Li, Hui, Lin, Zhiping
• Format: Article
• Language: English
• Subjects: Hippocampal sclerosis; Magnetic resonance imaging; Mesial temporal lobe epilepsy; Radiomics; T2-FLAIR
• ISSN: 0720-048X; 1872-7727; 1872-7727
• DOI: 10.1016/j.ejrad.2023.111082

Preoperative identification of hippocampal sclerosis (HS) is crucial to successful surgery for mesial temporal lobe epilepsy (MTLE). We aimed to investigate the diagnostic performance of hippocampal radiomics models based on T2 fluid-attenuated inversion recovery (FLAIR) images in MTLE with HS. We analysed 210 cases, including 172 HS pathology-confirmed cases (100 magnetic resonance imaging [MRI]-positive cases [MRI+HS], 72 MRI-negative HS cases [MRI−HS]), and 38 healthy controls (HC). The hippocampus was delineated slice by slice on an oblique coronal plane by a T2-FLAIR sequence, perpendicular to the hippocampus’s long axis, to obtain a three-dimensional region of interest. Radiomics were processed using Artificial Intelligence Kit software; logistic regression radiomics models were constructed. The model evaluation indexes included the area under the curve (AUC), accuracy, sensitivity, and specificity. The respective AUC, accuracy, sensitivity, and specificity were 0.863, 81.4%, 78.0%, and 84.6% between the MRI−HS and HC groups in the training set and 0.855, 75.0%, 68.2%, and 81.8% in the test set; 0.975, 95.0%, 92.9%, and 98.0% between the MRI+HS and HC groups in the training set and 0.954, 88.7%, 90.0%, and 87.0% in the test set; and 0.912, 84.3%, 83.3%, and 86.5% between the MTLE and HC groups in the training set and 0.854, 79.7%, 80.8%, and 77.3% in the test set. The AUC values of the comparative radiomics models were >0.85, indicating good diagnostic efficiency. The hippocampal radiomics models based on T2-FLAIR images can help diagnose MTLE with HS. They can be used as biological markers for MTLE diagnosis.