ceRNA networks in gynecological cancers progression and resistance

Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mechanism and specific diagnostic biomarkers. Many studies have demonstrated that competing endogenous RNAs...

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Bibliographic Details
Published in:Journal of drug targeting 2023-12, Vol.31 (9), p.920-930
Main Authors: Wu, Shuqin, Zhong, Baoshan, Yang, Yuxin, Wang, Yurou, Pan, Zezheng
Format: Article
Language:English
Subjects:
Biomarkers
Female
Gene Expression Regulation, Neoplastic - genetics
Gene Regulatory Networks
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
Neoplasms - genetics
RNA, Long Noncoding - genetics
RNA, Messenger - metabolism
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Summary:Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mechanism and specific diagnostic biomarkers. Many studies have demonstrated that competing endogenous RNAs (ceRNAs) modulate the progression and resistance of gynecological cancer through microRNA (miRNA)-mediated mechanisms, which affect gene expression in multiple cancer-related pathways. Here we review studies on the involvement of the ceRNA hypothesis in the progression and resistance of gynaecological cancers to validate some ceRNAs as therapeutic targets and predictive biomarkers.
ISSN:1061-186X
1029-2330
DOI:10.1080/1061186X.2023.2261079