Clinical Value of Endoscopic Esophageal Screening in Head and Neck Squamous Cell Carcinoma Patients

Objective To investigate the clinical benefit of routine esophageal screening in newly diagnosed head and neck squamous cell carcinoma (HNSCC) patients. Study Design Retrospective cohort study. Setting Tertiary medical center. Methods This retrospective study selected newly diagnosed HNSCC patients...

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2024-01, Vol.170 (1), p.141-150
Main Authors: Chen, Wei‐Chih, Wu, Ching‐Nung, Wang, Yu‐Ming, Chiu, Tai‐Jan, Wu, Shao‐Chun, Yang, Yao‐Hsu, Luo, Sheng‐Dean
Format: Article
Language:English
Subjects:
esophageal cancer
esophagoscopy
panendoscopy
prevalence
survival
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Summary:Objective To investigate the clinical benefit of routine esophageal screening in newly diagnosed head and neck squamous cell carcinoma (HNSCC) patients. Study Design Retrospective cohort study. Setting Tertiary medical center. Methods This retrospective study selected newly diagnosed HNSCC patients from the Chang Gung Research Database between January 2007 and December 2019. Patients who underwent endoscopic esophageal examinations within 2 months of the initial diagnosis of HNSCC were included in the screening group. The clinical outcomes of the screening and nonscreening groups were analyzed. Results In total, 13,627 HNSCC patients were included, comprising 1032 females and 12,640 males (mean age 55.0 years), and the esophageal screening group included 7033 (51.4%) patients. The prevalence rate of esophageal tumors was 4.5%. Hypopharyngeal cancer patients were the most likely to have (13.4%) second primary esophageal tumors. The American Joint Committee on Cancer stage of the esophageal tumor was lower in the esophageal screening group than in the nonesophageal screening group. The oral, oropharyngeal, and hypopharyngeal cancer patients in the esophageal screening group had better survival outcomes than their counterparts in the nonesophageal screening group. Conclusion Endoscopic esophageal screening of newly diagnosed HNSCC patients can detect esophageal tumors at an early stage and improve overall survival. Esophageal screening could be a routine survey in HNSCC patients, particularly those with lifestyle risk factors and in countries with a high prevalence of esophageal cancer.
ISSN:0194-5998
1097-6817
DOI:10.1002/ohn.519