Spontaneously hatching human blastocyst is associated with high development potential and live birth rate in vitrified‐warmed single blastocyst transfer: A retrospective cohort study

Objective To investigate the effect of hatching status on predicting pregnancy outcomes in single vitrified‐warmed blastocyst transfer (SVBT) by objectively subdividing pre‐implantation blastocysts according to hatching status. Methods This retrospective study included 817 SVBT cycles performed betw...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2024-01, Vol.164 (1), p.315-323
Main Authors: Han, E Jung, Park, Jae Kyun, Eum, Jin Hee, Bang, Soyoung, Kim, Ji Won, Lee, Woo Sik
Format: Article
Language:English
Subjects:
Birth Rate
Blastocyst
blastocyst hatching
Cryopreservation - methods
Embryo Transfer - methods
Female
Humans
Infant, Newborn
Live Birth - epidemiology
live birth rate
neonatal outcome
Pregnancy
Pregnancy Rate
Retrospective Studies
single embryo transfer
Vitrification
vitrified‐warmed blastocyst transfer
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Summary:Objective To investigate the effect of hatching status on predicting pregnancy outcomes in single vitrified‐warmed blastocyst transfer (SVBT) by objectively subdividing pre‐implantation blastocysts according to hatching status. Methods This retrospective study included 817 SVBT cycles performed between January 2016 and December 2017. Transferred embryos were categorized according to their hatching status as follows: group I (n = 147), non‐hatching blastocysts; group II (n = 484), hatching blastocysts; and group III (n = 186), completely hatched blastocysts. Hatching blastocysts (group II) were then classified based on the ratio of the blastocystic diameter outside and inside the zona pellucida into early (n = 185), mid‐ (n = 103), and late (n = 196) hatching stages. Implantation rate (IR), clinical pregnancy rate (CPR), live birth rate (LBR), multiple pregnancy rate (MPR), miscarriage rate, and neonatal outcomes were evaluated. Results For groups I, II, and III, respectively, the results were as follows: IR (28.6%, 43.6%, and 53.8%; P 
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.15084