Relationship between 4-month functional brain network topology and 24-month neurodevelopmental outcome in children with congenital heart disease

• Published in: European journal of paediatric neurology 2023-11, Vol.47, p.47-59
• Main Authors: Provost, Sarah, Fourdain, Solène, Vannasing, Phetsamone, Tremblay, Julie, Roger, Kassandra, García-Puente, Yalina, Doussau, Amélie, Vinay, Marie-Claude, Von Siebenthal, Zorina, Paquette, Natacha, Poirier, Nancy, Gallagher, Anne
• Format: Article
• Language: English
• Subjects: Brain function; Congenital heart disease; fNIRS; Functional network topology; Graph theory; Neurodevelopment
• ISSN: 1090-3798; 1532-2130
• DOI: 10.1016/j.ejpn.2023.09.005

Survivors of complex forms of congenital heart disease (CHD)∗ are at high risk of neurodevelopmental disabilities. Neuroimaging studies have pointed to brain anomalies and immature networks in infants with CHD, yet less is known about their functional network topology and associations with neurodevelopment. To characterize the functional network topology in 4-month-old infants with repaired CHD, we compared graph theory metrics measured using resting-state functional near-infrared spectroscopy (rs-fNIRS) between infants with CHD (n = 22) and healthy controls (n = 30). We also investigated the moderating effect of graph theory metrics on the relationship between group (CHD vs. Controls) and developmental outcomes at 24 months. At 4 months, both groups presented similar functional brain network topology. At 24 months, children with CHD had lower scores on the language scale and the expressive communication subscale of the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), as well as lower scores on the Grammatical Form scale of the MacArthur-Bates Communicative Development Inventory (MBCDI). The relationship between group and expressive language was moderated by the normalized characteristic path length (λ) and the degree (k). Although infants with CHD have functional brain topology similar to that of healthy controls, our findings suggest that they do not benefit from an optimal functional brain organization in comparison with healthy infants. •At 4 months, infants with congenital heart disease (CHD) presented similar functional brain network topology than healthy controls.•At 24 months, children with CHD showed lower expressive language compared to healthy controls.•The relationship between groups (CHD vs. Controls) and the expressive language was moderated by two graph theoretical metrics: The normalized characteristic path length (λ) and the degree (k).•Our findings suggest that children with CHD do not benefit from an optimal functional brain organization compared to healthy controls.