The association of preconceptional folic acid supplementation with gestational age and preterm birth risk in twin pregnancies: a prospective cohort study in China

Purpose This study aims to explore the association of maternal preconceptional folic acid (FA) supplementation with gestational age and preterm birth in twin pregnancies, and whether the association varies by chorionicity or conception mode. Methods From November 2018 to December 2021, the informati...

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Bibliographic Details
Published in:European journal of nutrition 2024-02, Vol.63 (1), p.107-119
Main Authors: Xia, Yuanqing, Huang, Lili, Long, Zichong, Chen, Yiting, Gao, Li, Hua, Renyi, Li, Shenghui, Wang, Yanlin
Format: Article
Language:English
Subjects:
Age
Birth
Chemistry
Chemistry and Materials Science
Cohort analysis
Dietary Supplements
Female
Folic acid
Folic Acid - therapeutic use
Gestational Age
Humans
Infant, Newborn
Nutrition
Original Contribution
Pregnancy
Pregnancy, Twin
Premature birth
Premature Birth - epidemiology
Premature Birth - prevention & control
Prospective Studies
Regression analysis
Reproductive technologies
Retrospective Studies
Supplements
Twins
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Summary:Purpose This study aims to explore the association of maternal preconceptional folic acid (FA) supplementation with gestational age and preterm birth in twin pregnancies, and whether the association varies by chorionicity or conception mode. Methods From November 2018 to December 2021, the information of FA supplementation and pregnancy outcomes were collected in twin pregnant women. The linear regression models and the logistic regression were used to test the association of preconceptional FA supplementation with gestational age at delivery and preterm birth and premature rupture of membranes (PROM). Results A total of 416 twin pregnancies were included. Compared with no use in twins, maternal preconceptional FA use was associated with a 0.385-week longer gestational age (95% CI 0.019–0.751) and lower risk of preterm birth 
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-023-03223-8