Less invasive surfactant administration methods: Who, what and how

Surfactant administration via an endotracheal tube (ETT) has been the standard of care for infants with respiratory distress syndrome for decades. As non-invasive ventilation has become commonplace in the NICU, methods for administering surfactant without use of an ETT have been developed. These met...

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Bibliographic Details
Published in:Journal of perinatology 2024-04, Vol.44 (4), p.472-477
Main Authors: Guthrie, S. O., Roberts, K. D.
Format: Article
Language:English
Subjects:
692/308/575
692/699/1785
Aerosols
Airway management
Babies
Cardiac arrhythmia
Catheters
Clinical medicine
Drug administration
Extubation
FDA approval
Humans
Infant, Newborn
Infant, Premature
Intubation, Intratracheal - methods
Laryngoscopy
Larynx
Lung diseases
Medical instruments
Medicine
Medicine & Public Health
Methods
Neonatal care
Pediatric Surgery
Pediatrics
Pulmonary Surfactants - therapeutic use
Respiratory distress syndrome
Respiratory Distress Syndrome, Newborn - drug therapy
Review Article
Standard of care
Surface-Active Agents - therapeutic use
Surfactants
Ventilators
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Description
Summary:Surfactant administration via an endotracheal tube (ETT) has been the standard of care for infants with respiratory distress syndrome for decades. As non-invasive ventilation has become commonplace in the NICU, methods for administering surfactant without use of an ETT have been developed. These methods include thin catheter techniques (LISA, MIST), aerosolization/ nebulization, and surfactant administration through laryngeal (LMA) or supraglottic airways (SALSA). This review will describe these methods and discuss considerations and implementation into clinical practice.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-023-01778-2