Serum proteomic biomarkers diagnostic of knee osteoarthritis

To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics. We conducted multiple reaction monitoring mass spectrometry analysis of 107 peptides in baseline sera of two cohorts: the Foundation for National Institutes of Health (NIH) (n = 596 Kellgre...

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2024-03, Vol.32 (3), p.329-337
Main Authors: Kraus, Virginia Byers, Reed, Alexander, Soderblom, Erik J., Golightly, Yvonne M., Nelson, Amanda E., Li, Yi-Ju
Format: Article
Language:English
Subjects:
Biomarkers
Coagulation
Complement
Diagnostic
Humans
Knee Joint - pathology
Marker
Mass spectrometry
Osteoarthritis
Osteoarthritis, Knee - diagnostic imaging
Peptides
Proteomics
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Summary:To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics. We conducted multiple reaction monitoring mass spectrometry analysis of 107 peptides in baseline sera of two cohorts: the Foundation for National Institutes of Health (NIH) (n = 596 Kellgren-Lawrence (KL) grade 1–3 knee OA participants); and the Johnston County Osteoarthritis Project (n = 127 multi-joint controls free of radiographic OA of the hands, hips, knees (bilateral KL=0), and spine). Data were split into (70%) training and (30%) testing sets. Diagnostic peptide and clinical data predictors were selected by random forest (RF); selection was based on association (p 
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2023.09.007