Cell‐free protein synthesis system: A new frontier for sustainable biotechnology‐based products

Cell‐free protein synthesis (CFPS) system is an innovative technology with a wide range of potential applications that could challenge current thinking and provide solutions to environmental and health issues. CFPS system has been demonstrated to be a successful way of producing biomolecules in a va...

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Bibliographic Details
Published in:Biotechnology and applied biochemistry 2023-12, Vol.70 (6), p.2136-2149
Main Authors: Maharjan, Anoth, Park, Jung‐Ho
Format: Article
Language:English
Subjects:
Biomolecules
Biotechnology
bio‐therapeutic products
CFPS system
Protein biosynthesis
Protein synthesis
Proteins
synthetic biology
therapeutic proteins
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Summary:Cell‐free protein synthesis (CFPS) system is an innovative technology with a wide range of potential applications that could challenge current thinking and provide solutions to environmental and health issues. CFPS system has been demonstrated to be a successful way of producing biomolecules in a variety of applications, including the biomedical industry. Although there are still obstacles to overcome, its ease of use, versatility, and capacity for integration with other technologies open the door for it to continue serving as a vital instrument in synthetic biology research and industry. In this review, we mainly focus on the cell‐free based platform for various product productions. Moreover, the challenges in the bio‐therapeutic aspect using cell‐free systems and their future prospective for the improvement and sustainability of the cell free systems.
ISSN:0885-4513
1470-8744
DOI:10.1002/bab.2514