Impact of chemical modifications on the antimicrobial and hemolytic activity of helical amphipathic peptide Lasioglossin LL-III

Insect venom is abundant in potential antimicrobial peptides (AMPs), which can serve as novel alternatives to conventional antibiotics. Among them, Lasioglossin III LL-III ) is a promising candidate with a broad spectrum against many fungi strains and both types of bacteria, whereas almost non-toxic...

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Published in:Amino acids 2023-11, Vol.55 (11), p.1531-1544
Main Authors: Bui Thi Phuong, Hai, Le Uyen, Chi, Doan Ngan, Hoa, Luong Xuan, Huy
Format: Article
Language:English
Subjects:
Amino acids
Analytical Chemistry
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Bacteria
Biochemical Engineering
Biochemistry
Biological activity
Biomedical and Life Sciences
Blood
Cancer
Erythrocytes
Gram-positive bacteria
Hydrocarbons
Insects
Leukemia
Life Sciences
Mini Review
Neurobiology
Peptides
Proteomics
Vagina
Venom
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creator Bui Thi Phuong, Hai
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description Insect venom is abundant in potential antimicrobial peptides (AMPs), which can serve as novel alternatives to conventional antibiotics. Among them, Lasioglossin III LL-III ) is a promising candidate with a broad spectrum against many fungi strains and both types of bacteria, whereas almost non-toxic to red blood cells. Many chemical approaches have been recently applied to improve its pharmacological properties and provide useful information regarding structure–activity relationships. Hence, this review focused on highlighting the lesson learned from each modification and supporting the future design of potent, selective, and metabolically stable AMPs.
doi_str_mv 10.1007/s00726-023-03326-w
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subjects Amino acids
Analytical Chemistry
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Bacteria
Biochemical Engineering
Biochemistry
Biological activity
Biomedical and Life Sciences
Blood
Cancer
Erythrocytes
Gram-positive bacteria
Hydrocarbons
Insects
Leukemia
Life Sciences
Mini Review
Neurobiology
Peptides
Proteomics
Vagina
Venom
title Impact of chemical modifications on the antimicrobial and hemolytic activity of helical amphipathic peptide Lasioglossin LL-III
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